Nov. 24 (UPI) — The hormone lipocalin-2, discovered naturally in people and mice, may doubtlessly treat weight problems, a brand new study discovered.

The LCN2 hormone, secreted by bone cells and located naturally in mice and people, has beforehand been proven to make mice really feel full after a meal, researchers say.

“LCN2 acts as a sign for satiety after a meal, main mice to restrict their meals consumption, and it does this by appearing on the hypothalamus throughout the mind,” lead study writer Peristera-loanna Petropoulou mentioned in a press launch.

“We wished to see whether or not LCN2 has comparable results in people, and whether or not a dose of it might be capable to cross the blood-brain barrier,” mentioned Petropoulou, who was a Columbia College postdoctoral analysis scientist in the course of the study and is now on the Helmholtz Diabetes Middle.

Researchers discovered that the LCN2 hormone was additionally related to a lowered feeling of hunger after a meal, in accordance with the study, printed Tuesday within the journal eLife.

Analysts carried out the study by analyzing the quantity of LCN2 in study members blood earlier than and after a meal.

They discovered a rise in LCN2 ranges in folks of regular weight coinciding with a sense of satiety after a meal, however decreased ranges in individuals who have been obese or had weight problems.

Researchers mentioned this means that decrease ranges of LCN2 may contribute to weight problems and that the hormone may have potential as an weight problems therapy.

“We have now proven that LCN2 crosses to the mind, makes its approach to the hypothalamus and suppresses meals consumption in non-human primates,” mentioned senior study writer Stavroula Kousteni.

“Our outcomes present that the hormone can curb urge for food with negligible toxicity and lay the groundwork for the following stage of LCN2 testing for scientific use,” mentioned Kousteni, a Columbia College professor of physiology and mobile biophysics.

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